Umesh Masharani, MBBS

Clinic Chief
Endocrinology
+1 415 353-2350

Dr. Masharani is a Clinical Professor of Endocrinology and Metabolism in the Department of Medicine, UCSF. He has an active clinical practice treating patients with Diabetes and other endocrine disorders. Dr Masharani also is a Co-Investigator on a number of NIH funded diabetes studies at UCSF. His research includes studies evaluating the effect of chromium and alpha lipoic acid on insulin resistance, and anti-CD3 antibodies on new onset Type 1 Diabetes and multi-ethnic studies addressing the interactive relationships among disease management, glucose control and depression in patients with Type 2 Diabetes. As a member of the UCSF Islet Transplant Group, Dr Masharani assists in managing diabetes of patients admitted to UCSF for islet transplantation evaluation. He has recently published a book “Diabetes DeMystified” (McGraw Hill 2007).

Dr. Masharani attended Oxford University and received his medical degree from Middlesex Hospital, London. He is board certified in Internal Medicine and Endocrinology and Metabolism.

Publications: 

Metastatic insulinoma-outcomes in the current era.

The oncologist

Masharani U, Lindsay S, Moon F, Paciorek A, Bergsland E

The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors.

Journal of diabetes science and technology

Klonoff DC, Freckmann G, Pleus S, Kovatchev BP, Kerr D, Tse CC, Li C, Agus MSD, Dungan K, Voglová Hagerf B, Krouwer JS, Lee WA, Misra S, Rhee SY, Sabharwal A, Seley JJ, Shah VN, Tran NK, Waki K, Worth C, Tian T, Aaron RE, Rutledge K, Ho CN, Ayers AT, Adler A, Ahn DT, Aktürk HK, Al-Sofiani ME, Bailey TS, Baker M, Bally L, Bannuru RR, Bauer EM, Bee YM, Blanchette JE, Cengiz E, Chase JG, Y Chen K, Cherñavvsky D, Clements M, Cote GL, Dhatariya KK, Drincic A, Ejskjaer N, Espinoza J, Fabris C, Fleming GA, Gabbay MAL, Galindo RJ, Gómez-Medina AM, Heinemann L, Hermanns N, Hoang T, Hussain S, Jacobs PG, Jendle J, Joshi SR, Koliwad SK, Lal RA, Leiter LA, Lind M, Mader JK, Maran A, Masharani U, Mathioudakis N, McShane M, Mehta C, Moon SJ, Nichols JH, O'Neal DN, Pasquel FJ, Peters AL, Pfützner A, Pop-Busui R, Ranjitkar P, Rhee CM, Sacks DB, Schmidt S, Schwaighofer SM, Sheng B, Simonson GD, Sode K, Spanakis EK, Spartano NL, Umpierrez GE, Vareth M, Vesper HW, Wang J, Wright E, Wu AHB, Yeshiwas S, Zilbermint M, Kohn MA

Aging delays the suppression of lipolysis in the postprandial period.

Journal of applied physiology (Bethesda, Md. : 1985)

Osmond AD, Leija RG, Arevalo JA, Curl CC, Duong JJ, Huie MJ, Masharani U, Brooks GA

Delayed and Diminished Postprandial Lactate Shuttling in Healthy Older Men and Women.

American journal of physiology. Endocrinology and metabolism

Arevalo JA, Leija RG, Osmond AD, Curl CC, Duong JJ, Huie MJ, Masharani U, Brooks GA

EMBARK: A Randomized, Controlled Trial Comparing Three Approaches to Reducing Diabetes Distress and Improving HbA1c in Adults With Type 1 Diabetes.

Diabetes care

Hessler DM, Fisher L, Guzman S, Strycker L, Polonsky WH, Ahmann A, Aleppo G, Argento NB, Henske J, Kim S, Stephens E, Greenberg K, Masharani U

Altered Glucose Kinetics Occurs With Aging, A New Outlook on Metabolic Flexibility.

American journal of physiology. Endocrinology and metabolism

Curl CC, Leija RG, Arevalo JA, Osmond AD, Duong JJ, Huie MJ, Masharani U, Horning MA, Brooks GA

Potential Mediators for Treatment Effects of Novel Diabetes Medications on Cardiovascular and Renal Outcomes: A Meta-Regression Analysis.

Journal of the American Heart Association

Rodriguez-Valadez JM, Tahsin M, Masharani U, Park M, Hunink MGM, Yeboah J, Li L, Weber E, Berkalieva A, Avezaat L, Max W, Fleischmann KE, Ferket BS

Hospital Diabetes Meeting 2022.

Journal of diabetes science and technology

Huang J, Yeung AM, Nguyen KT, Xu NY, Preiser JC, Rushakoff RJ, Seley JJ, Umpierrez GE, Wallia A, Drincic AT, Gianchandani R, Lansang MC, Masharani U, Mathioudakis N, Pasquel FJ, Schmidt S, Shah VN, Spanakis EK, Stuhr A, Treiber GM, Klonoff DC

Diabetes Technology Meeting 2021.

Journal of diabetes science and technology

Xu NY, Nguyen KT, DuBord AY, Pickup J, Sherr JL, Teymourian H, Cengiz E, Ginsberg BH, Cobelli C, Ahn D, Bellazzi R, Bequette BW, Gandrud Pickett L, Parks L, Spanakis EK, Masharani U, Akturk HK, Melish JS, Kim S, Kang GE, Klonoff DC

The ubiquity of diabetes distress among adults with type 1 diabetes in an urban, academic practice: a template for intervention.

Diabetic medicine : a journal of the British Diabetic Association

Masharani U, Strycker LA, Fisher L

A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings.

Journal of diabetes science and technology

Klonoff DC, Wang J, Rodbard D, Kohn MA, Li C, Liepmann D, Kerr D, Ahn D, Peters AL, Umpierrez GE, Seley JJ, Xu NY, Nguyen KT, Simonson G, Agus MSD, Al-Sofiani ME, Armaiz-Pena G, Bailey TS, Basu A, Battelino T, Bekele SY, Benhamou PY, Bequette BW, Blevins T, Breton MD, Castle JR, Chase JG, Chen KY, Choudhary P, Clements MA, Close KL, Cook CB, Danne T, Doyle FJ, Drincic A, Dungan KM, Edelman SV, Ejskjaer N, Espinoza JC, Fleming GA, Forlenza GP, Freckmann G, Galindo RJ, Gomez AM, Gutow HA, Heinemann L, Hirsch IB, Hoang TD, Hovorka R, Jendle JH, Ji L, Joshi SR, Joubert M, Koliwad SK, Lal RA, Lansang MC, Lee WA, Leelarathna L, Leiter LA, Lind M, Litchman ML, Mader JK, Mahoney KM, Mankovsky B, Masharani U, Mathioudakis NN, Mayorov A, Messler J, Miller JD, Mohan V, Nichols JH, Nørgaard K, O'Neal DN, Pasquel FJ, Philis-Tsimikas A, Pieber T, Phillip M, Polonsky WH, Pop-Busui R, Rayman G, Rhee EJ, Russell SJ, Shah VN, Sherr JL, Sode K, Spanakis EK, Wake DJ, Waki K, Wallia A, Weinberg ME, Wolpert H, Wright EE, Zilbermint M, Kovatchev B

Disconnected Pancreatic Duct Syndrome: Pancreatitis of the Disconnected Pancreas and its Role in the Development of Diabetes Mellitus.

Clinical and translational gastroenterology

Thiruvengadam NR, Forde KA, Miranda J, Kim C, Behr S, Masharani U, Arain MA

A multidisciplinary approach to optimizing care of patients treated with alpelisib.

Breast (Edinburgh, Scotland)

Rugo HS, Lacouture ME, Goncalves MD, Masharani U, Aapro MS, O'Shaughnessy JA

Hyperlactatemia in diabetic ketoacidosis.

Diabetic medicine : a journal of the British Diabetic Association

Masharani U, Strycker LA, Lazar AA, Wu K, Brooks GA

Diabetes Technology Meeting 2020.

Journal of diabetes science and technology

Shang T, Zhang JY, Bequette BW, Raymond JK, Coté G, Sherr JL, Castle J, Pickup J, Pavlovic Y, Espinoza J, Messer LH, Heise T, Mendez CE, Kim S, Ginsberg BH, Masharani U, Galindo RJ, Klonoff DC

Estimating Long-Term Health Utility Scores and Expenditures for Cardiovascular Disease From the Medical Expenditure Panel Survey.

Circulation. Cardiovascular quality and outcomes

Morey JR, Jiang S, Klein S, Max W, Masharani U, Fleischmann KE, Hunink MGM, Ferket BS

LETTER TO THE EDITOR from Neinstein et al: Approach to the Patient with Thyrotoxicosis Using Telemedicine.

The Journal of clinical endocrinology and metabolism

Neinstein AB, Masharani U

Calcium Stimulation Test for Insulinoma Localization in an End-stage Renal Disease Patient on Diazoxide.

Journal of the Endocrine Society

Kim S, Conrad M, Chuang E, Cai L, Masharani U, Murphy EJ

Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva.

Orphanet journal of rare diseases

Kou S, De Cunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, Di Rocco M, Keen R, Al Mukaddam M, le Quan Sang KH, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC

Economic costs of implementing group interventions to reduce diabetes distress in adults with type 1 diabetes mellitus in the T1-REDEEM trial.

Journal of diabetes and its complications

Shumway M, Fisher L, Hessler D, Bowyer V, Polonsky WH, Masharani U

There is value in treating elevated levels of diabetes distress: the clinical impact of targeted interventions in adults with Type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association

Hessler D, Fisher L, Polonsky W, Strycker L, Parra J, Bowyer V, Dedhia M, Masharani U

Toward effective interventions to reduce diabetes distress among adults with type 1 diabetes: Enhancing?Emotion regulation and cognitive skills.

Patient education and counseling

Fisher L, Hessler D, Polonsky W, Strycker L, Bowyer V, Masharani U

Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva.

British journal of clinical pharmacology

Wentworth KL, Masharani U, Hsiao EC

T1-REDEEM: A Randomized Controlled Trial to Reduce Diabetes Distress Among Adults With Type 1 Diabetes.

Diabetes care

Fisher L, Hessler D, Polonsky WH, Masharani U, Guzman S, Bowyer V, Strycker L, Ahmann A, Basina M, Blumer I, Chloe C, Kim S, Peters AL, Shumway M, Weihs K, Wu P

Emotion regulation contributes to the development of diabetes distress among adults with type 1 diabetes.

Patient education and counseling

Fisher L, Hessler D, Polonsky W, Strycker L, Guzman S, Bowyer V, Blumer I, Masharani U

Diabetes distress is linked with worsening diabetes management over time in adults with Type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association

Hessler DM, Fisher L, Polonsky WH, Masharani U, Strycker LA, Peters AL, Blumer I, Bowyer V

11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy.

Annals of nuclear medicine

Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF

Diabetes distress in adults with type 1 diabetes: Prevalence, incidence and change over time.

Journal of diabetes and its complications

Fisher L, Hessler D, Polonsky W, Strycker L, Masharani U, Peters A

Prevalence of depression in Type 1 diabetes and the problem of over-diagnosis.

Diabetic medicine : a journal of the British Diabetic Association

Fisher L, Hessler DM, Polonsky WH, Masharani U, Peters AL, Blumer I, Strycker LA

A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Moassesfar S, Masharani U, Frassetto LA, Szot GL, Tavakol M, Stock PG, Posselt AM

A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting.

Calcified tissue international

Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC

Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes.

European journal of clinical nutrition

Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, Nolte Kennedy M, Frassetto L

Understanding the sources of diabetes distress in adults with type 1 diabetes.

Journal of diabetes and its complications

Fisher L, Polonsky WH, Hessler DM, Masharani U, Blumer I, Peters AL, Strycker LA, Bowyer V

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ

Prediabetic living kidney donors have preserved kidney function at 10 years after donation.

Transplantation

Chandran S, Masharani U, Webber AB, Wojciechowski DM

Impact of baseline patient characteristics on interventions to reduce diabetes distress: the role of personal conscientiousness and diabetes self-efficacy.

Diabetic medicine : a journal of the British Diabetic Association

Fisher L, Hessler D, Masharani U, Strycker L

Reductions in regimen distress are associated with improved management and glycemic control over time.

Diabetes care

Hessler D, Fisher L, Glasgow RE, Strycker LA, Dickinson LM, Arean PA, Masharani U

Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action.

Diabetes care

Draznin B, Gilden J, Golden SH, Inzucchi SE, , Baldwin D, Bode BW, Boord JB, Braithwaite SS, Cagliero E, Dungan KM, Falciglia M, Figaro MK, Hirsch IB, Klonoff D, Korytkowski MT, Kosiborod M, Lien LF, Magee MF, Masharani U, Maynard G, McDonnell ME, Moghissi ES, Rasouli N, Rubin DJ, Rushakoff RJ, Sadhu AR, Schwartz S, Seley JJ, Umpierrez GE, Vigersky RA, Low CC, Wexler DJ

REDEEM: a pragmatic trial to reduce diabetes distress.

Diabetes care

Fisher L, Hessler D, Glasgow RE, Arean PA, Masharani U, Naranjo D, Strycker LA

Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity.

BMC endocrine disorders

Masharani U, Gjerde C, McCoy S, Maddux BA, Hessler D, Goldfine ID, Youngren JF

Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?

Journal of magnetic resonance imaging : JMRI

Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, Masharani UB, Schwartz AV, Li X, Link TM

Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.

PloS one

Masharani UB, Maddux BA, Li X, Sakkas GK, Mulligan K, Schambelan M, Goldfine ID, Youngren JF

Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.

Transplantation

Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG

Patient age: a neglected factor when considering disease management in adults with type 2 diabetes.

Patient education and counseling

Hessler DM, Fisher L, Mullan JT, Glasgow RE, Masharani U

High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus.

The Journal of clinical endocrinology and metabolism

Burghardt AJ, Issever AS, Schwartz AV, Davis KA, Masharani U, Majumdar S, Link TM

Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG

Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome.

Journal of diabetes science and technology

Masharani U, Gjerde C, Evans JL, Youngren JF, Goldfine ID

Teplizumab therapy for type 1 diabetes.

Expert opinion on biological therapy

Masharani UB, Becker J

Clinical islet transplantation at the University of California, San Francisco.

Clinical transplants

Posselt AM, Szot GL, Frassetto LA, Masharani U, Stock PG

Daily negative mood affects fasting glucose in type 2 diabetes.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association

Skaff MM, Mullan JT, Almeida DM, Hoffman L, Masharani U, Mohr D, Fisher L

Update on systemic management of diabetes.

International ophthalmology clinics

Masharani U, Rushakoff RJ

A longitudinal study of affective and anxiety disorders, depressive affect and diabetes distress in adults with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association

Fisher L, Skaff MM, Mullan JT, Arean P, Glasgow R, Masharani U

Laparoscopic enucleation of insulinomas.

Archives of surgery (Chicago, Ill. : 1960)

Sweet MP, Izumisato Y, Way LW, Clark OH, Masharani U, Duh QY

Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T.

Magnetic resonance imaging

Li X, Youngren JF, Hyun B, Sakkas GK, Mulligan K, Majumdar S, Masharani UB, Schambelan M, Goldfine ID

Clinical depression versus distress among patients with type 2 diabetes: not just a question of semantics.

Diabetes care

Fisher L, Skaff MM, Mullan JT, Arean P, Mohr D, Masharani U, Glasgow R, Laurencin G

Negative life events and quality of life in adults with asthma.

Thorax

Archea C, Yen IH, Chen H, Eisner MD, Katz PP, Masharani U, Yelin EH, Earnest G, Blanc PD

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.

Diabetes

Herold KC, Gitelman SE, Masharani U, Hagopian W, Bisikirska B, Donaldson D, Rother K, Diamond B, Harlan DM, Bluestone JA

Impact of exogenous glucocorticoid use on salivary cortisol measurements among adults with asthma and rhinitis.

Psychoneuroendocrinology

Masharani U, Shiboski S, Eisner MD, Katz PP, Janson SL, Granger DA, Blanc PD

Impact of the home indoor environment on adult asthma and rhinitis.

Journal of occupational and environmental medicine

Blanc PD, Eisner MD, Katz PP, Yen IH, Archea C, Earnest G, Janson S, Masharani UB, Quinlan PJ, Hammond SK, Thorne PS, Balmes JR, Trupin L, Yelin EH

Insulin secretion in type 1 diabetes.

Diabetes

Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC

Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma.

Journal of lipid research

Campos E, Kotite L, Blanche P, Mitsugi Y, Frost PH, Masharani U, Krauss RM, Havel RJ

Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients.

Diabetologia

Roll U, Turck CW, Gitelman SE, Rosenthal SM, Nolte MS, Masharani U, Ziegler AG, Baekkeskov S

Troglitazone-induced fulminant hepatic failure. Acute Liver Failure Study Group.

Digestive diseases and sciences

Murphy EJ, Davern TJ, Shakil AO, Shick L, Masharani U, Chow H, Freise C, Lee WM, Bass NM

The endocrine complications of acquired immunodeficiency syndrome.

Advances in internal medicine

Masharani U, Schambelan M

Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus. Relationships with lipids, apolipoproteins, and premature coronary artery disease.

Atherosclerosis

Ordovas JM, Civeira F, Genest J, Craig S, Robbins AH, Meade T, Pocovi M, Frossard PM, Masharani U, Wilson PW

DNA polymorphisms of the apolipoprotein B gene in patients with premature coronary artery disease.

Atherosclerosis

Genest JJ, Ordovas JM, McNamara JR, Robbins AM, Meade T, Cohn SD, Salem DN, Wilson PW, Masharani U, Frossard PM

HinfI RFLP at the human renin (REN) gene locus.

Nucleic acids research

Masharani U

DraI and ScaI RFLPs at human tyrosine hydroxylase (TH) gene locus.

Nucleic acids research

Tinklenberg KJ, Masharani U, Coleman RT, Taylor J, Cawthorn R, Frossard P

EcoRI and NsiI RFLPs at a human PLA2 gene on chromosome 1.

Nucleic acids research

Masharani U, Coleman RT, Johnson LK, Seilhamer JJ

BanII and ScaI RFLPs at the human p53 gene locus.

Nucleic acids research

Masharani U, Wolf D, Frossard PM

Two EcoT14I RFLPs at the human renin (REN) gene locus.

Nucleic acids research

Masharani U, Baxter JD, Frossard PM

MboI RFLP at the human renin (ren) gene locus.

Nucleic acids research

Masharani U, Frossard PM